A major Ku?

Ku autoantigen is a potential major cause of nonspecific bands in electrophoretic mobility shift assays.

Role of a major autoepitope in forming the DNA binding site of the p70 (Ku) antigen

The Ku antigen is a heterodimer consisting of 70- and 80-kD protein subunits that binds to termini of double-stranded DNA. DNA binding appears to be mediated partly by the 70-kD (p70) subunit, but the precise mechanism of its association with DNA is unclear. High-titer autoantibodies in sera from certain patients with systemic lupus erythematosus recognize at least eight distinct epitopes of Ku...

Ku autoantigen: a multifunctional DNA-binding protein.

Ku is a heterodimeric protein composed of approximately 70- and approximately 80-kDa subunits (Ku70 and Ku80) originally identified as an autoantigen recognized by the sera of patients with autoimmune diseases. Ku has high binding affinity for DNA ends and that is why originally it was known as a DNA end binding protein, but now it is known to also bind the DNA structure at nicks, gaps, hairpin...

33-38 Ku

and other STDs. Men in their 20s are more likely to be sexually active and are less likely to use condoms than teenagers.4 Their high-risk sexual behavior also leads to increased risk for disease: Half of all new HIV infections in the United States are among people younger than 25,5 and young men aged 20–24 have the highest rate of gonorrhea infection among all male age-groups.6 In contrast to ...

Ku circles the telomere?

all tumor cells are created equal when it comes to telomere biology. Tumor cells that do not express telomerase appear to utilize a telomerase-independent process to maintain telomere length, known as ALT for alternative lengthening of telomeres [1]. Although the existence of this process has been recognized for some time, the precise mechanism by which telomeres are maintained in these cells h...